Phosphoinositide (PI) phosphatases such as the SH2 domain‐containing inositol 5‐phosphatases 1/2 (SHIP1 and 2) are important signalling enzymes in human physiopathology. SHIP1/2 interact with a large number of immune and growth factor receptors. Tyrosine phosphorylation of SHIP1/2 has been considered to be the determining regulatory modification. However, here we present a hypothesis, based on recent key publications, highlighting the determining role of Ser/Thr phosphorylation in regulating several key properties of SHIP1/2. Since a subunit of the Ser/Thr phosphatase PP2A has been (...) shown to interact with SHIP2, a putative mechanism for reversing SHIP2 Ser/Thr phosphorylation can be anticipated. PI phosphatases are potential target molecules in human diseases, particularly, but not exclusively, in cancer and diabetes. Therefore, this novel regulatory mechanism deserves further attention in the hunt for discovering novel or complementary therapeutic strategies. This mechanism may be more broadly involved in regulating PI signalling in the case of synaptojanin1 or the phosphatase, tensin homolog, deleted on chromosome TEN.Editor's suggested further reading in BioEssays: Pairing phosphoinositides with calcium ions in endolysosomal dynamics Abstract. (shrink)

William S. Robinson has for many years written insightfully about the mind-body problem. In Understanding Phenomenal Consciousness he focuses on sensory experience and perception qualities such as colours, sounds and odours to present a dualistic view of the mind, called Qualitative Event Realism, that goes against the dominant materialist views. This theory is relevant to the development of a science of consciousness which is now being pursued not only by philosophers but by researchers in psychology and the brain sciences. This (...) provocative book will interest students and professionals who work in the philosophy of mind and will also have cross-disciplinary appeal in cognitive psychology and the brain sciences. (shrink)

In various contexts and for various reasons, writers often define cognitive processes and architectures as those involving representational states and structures. Similarly, cognitive theories are also often delineated as those that invoke representations. In this paper, I present several reasons for rejecting this way of demarcating the cognitive. Some of the reasons against defining cognition in representational terms are that doing so needlessly restricts our theorizing, it undermines the empirical status of the representational theory of mind, and it encourages wildly (...) deflationary and explanatorily vacuous conceptions of representation. After criticizing this outlook, I sketch alternative ways we might try to capture what is distinctive about cognition and cognitive theorizing. (shrink)

How should we make decisions when we're uncertain about what we ought, morally, to do? Decision-making in the face of fundamental moral uncertainty is underexplored terrain: MacAskill, Bykvist, and Ord argue that there are distinctive norms by which it is governed, and which depend on the nature of one's moral beliefs.

Critics of SRI have said little about the integrity of corporate representations resulting in screening inclusion or exclusion. This is surprising given social and environmental accounting research that finds corporate posturing and deception in the absence of external verification, and a parallel body of literature describing corporate "greenwashing" and other forms of corporate disinformation. In this paper I argue that the problems and challenges of ensuring fair and accurate corporate social reporting mirror those accompanying corporate compliance with law. Similarities and (...) points of convergence between social reporting and corporate compliance are discussed, along with proposals for reform. (shrink)

The logical properties of the 'if-then' connective of ordinary English differ markedly from the logical properties of the material conditional of classical, two-valued logic. This becomes apparent upon examination of arguments in conversational English which involve (noncounterfactual) usages of if-then'. A nonclassical system of propositional logic is presented, whose conditional connective has logical properties approximating those of 'if-then'. This proposed system reduces, in a sense, to the classical logic. Moreover, because it is equivalent to a certain nonstandard three-valued logic, its (...) decision procedure is almost as efficient as that of the classical logic. It therefore provides a rational and convenient system in which to formalize English arguments. (shrink)

The use of multiple means of determination to “triangulate” on the existence and character of a common phenomenon, object, or result has had a long tradition in science but has seldom been a matter of primary focus. As with many traditions, it is traceable to Aristotle, who valued having multiple explanations of a phenomenon, and it may also be involved in his distinction between special objects of sense and common sensibles. It is implicit though not emphasized in the distinction between (...) primary and secondary qualities from Galileo onward. It is arguably one of several conceptions involved in Whewell’s method of the “consilience of inductions” (Laudan 1971) and is to be found in several places in Peirce. (From M. Brewer and B. Collins, eds., (1981); Scientific Inquiry in the Social Sciences (a festschrift for Donald T. Campbell), San Francisco: Jossey-Bass, pp. 123–162.). (shrink)

The larger project of which this volume forms part is an attempt to craft a coherent doctrine of divine eternity and God's relationship to time.

We are often unsure about what we ought to do. This can be because we lack empirical knowledge, such as the extent to which future generations will be harmed by climate change. It can also be because we lack normative knowledge, such as the relative moral importance of the interests of present people and the interests of future people. However, though the question of how one ought to act under empirical uncertainty has been addressed extensively by both economists and philosophers---with (...) expected utility theory providing the standard formal framework---the question of how one ought to act under normative uncertainty is comparatively neglected. My thesis attempts to address this gap. -/- In my thesis I develop a view that I call metanormativism: that there are second-order norms that govern action that are relative to a decision-maker's uncertainty about first-order norms. -/- In the first part of the thesis, I defend one specific metanormative view: that under normative uncertainty decision-makers should maximise expected choice-worthiness, treating normative uncertainty analogously with empirical uncertainty. Drawing on the analogy between decision-making under normative uncertainty and social choice theory, I defend this view at length in response to the problem of merely ordinal theories and the problem of intertheoretic value comparisons. -/- In the second part of the thesis, I explore the implications of metanormativism for other philosophical issues. I argue that it has important consequences regarding the theory of rational action in the face of incomparable values, the causal/evidential debate in decision-theory, and our assessment of the value of moral philosophy. (shrink)

We advance an account that grounds cognition, specifically decision-making, in an activity all organisms as autonomous systems must perform to keep themselves viable—controlling their production mechanisms. Production mechanisms, as we characterize them, perform activities such as procuring resources from their environment, putting these resources to use to construct and repair the organism's body and moving through the environment. Given the variable nature of the environment and the continual degradation of the organism, these production mechanisms must be regulated by control mechanisms (...) that select when a production is required and how it should be carried out. To operate on production mechanisms, control mechanisms need to procure information through measurement processes and evaluate possible actions. They are making decisions. In all organisms, these decisions are made by multiple different control mechanisms that are organized not hierarchically but heterarchically. In many cases, they employ internal models of features of the environment with which the organism must deal. Cognition, in the form of decision-making, is thus fundamental to living systems which must control their production mechanisms. (shrink)

First-order logic. The origin of modern foundational studies. Frege's system and the paradoxes. The teory of types. Zermelo-Fraenkel set theory. Hilbert's program and Godel's incompleteness theorems. The foundational systems of W.V. Quine. Categorical algebra.

The formal systems of logic have ordinarily been regarded as independent of biology, but recent developments in evolutionary theory suggest that biology and logic may be intimately interrelated. In this book, William Cooper outlines a theory of rationality in which logical law emerges as an intrinsic aspect of evolutionary biology. This biological perspective on logic, though at present unorthodox, could change traditional ideas about the reasoning process. Cooper examines the connections between logic and evolutionary biology and illustrates how logical rules (...) are derived directly from evolutionary principles, and therefore have no independent status of their own. Laws of decision theory, utility theory, induction, and deduction are reinterpreted as natural consequences of evolutionary processes. Cooper's connection of logical law to evolutionary theory ultimately results in a unified foundation for an evolutionary science of reason. It will be of interest to professionals and students of philosophy of science, logic, evolutionary theory, and cognitive science. (shrink)

In this paper we provide a psychological account of the nature and development of explanation. We propose that an explanation is an account that provides a conceptual framework for a phenomenon that leads to a feeling of understanding in the reader/hearer. The explanatory conceptual framework goes beyond the original phenomenon, integrates diverse aspects of the world, and shows how the original phenomenon follows from the framework. We propose that explanations in everyday life are judged on the criteria of empirical accuracy, (...) scope, consistency, simplicity, and plausibility. We conclude that explanations in science are evaluated by the same criteria, plus those of precision, formalisms, and fruitfulness. We discuss several types of explanation that are used in everyday life – causal/mechanical, functional, and intentional. We present evidence to show that young children produce explanations that have the same essential form as those used by adults. We also provide evidence that children use the same evaluation criteria as adults, but may not apply those additional criteria for the evaluation of explanations that are used by scientists. (shrink)

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1902 Excerpt:...earth. r' = radius of moon, or other body. P = moon's horizontal parallax = earth's angular semidiameter as seen from the moon. f = moon's angular semidiameter. Now = P (in circular measure), r'-r = r (in circular measure);.'. r: r':: P: P', or (radius of earth): (radios of (...) moon):: (moon's parallax): (moon's semidiameter). Examples. 1. Taking the moon's horizontal parallax as 57', and its angular diameter as 32', find its radius in miles, assuming the earth's radius to be 4000 miles. Here moon's semidiameter = 16';.-. 4000::: 57': 16';.-. r = 400 16 = 1123 miles. 2. The sun's horizontal parallax being 8"8, and his angular diameter 32V find his diameter in miles. ' Am. 872,727 miles. 3. The synodic period of Venus being 584 days, find the angle gained in each minute of time on the earth round the sun as centre. Am. l"-54 per minute. 4. Find the angular velocity with which Venus crosses the sun's disc, assuming the distances of Venus and the earth from the sun are as 7 to 10, as given by Bode's Law. Since (fig. 50) S V: VA:: 7: 3. But Srhas a relative angular velocity round the sun of l"-54 per minute (see Example 3); therefore, the relative angular velocity of A V round A is greater than this in the ratio of 7: 3, which gives an approximate result of 3"-6 per minute, the true rate being about 4" per minute. Annual ParaUax. 95. We have already seen that no displacement of the observer due to a change of position on the earth's surface could apparently affect the direction of a fixed star. However, as the earth in its annual motion describes an orbit of about 92 million miles radius round the sun, the different positions in space from which an observer views the fixed stars from time to time throughout the year must be separated... (shrink)

Efforts to institutionalize ethics in corporations have been discussed without first addressing the desirability of norm conformity or the possibility that the means used to elicit conformity will be coercive. This article presents a theoretical context, grounded in models of social control, within which ethics initiatives may be evaluated. Ethics initiatives are discussed in relation to variables that already exert control in the workplace, such as environmental controls, organizational controls, and personal controls.

Most philosophical accounts of emergence are incompatible with reduction. Most scientists regard a system property as emergent relative to properties of the system's parts if it depends upon their mode of organization--a view consistent with reduction. Emergence can be analyzed as a failure of aggregativity--a state in which "the whole is nothing more than the sum of its parts." Aggregativity requires four conditions, giving tools for analyzing modes of organization. Differently met for different decompositions of the system, and in different (...) degrees, these conditions provide powerful evaluation criteria for choosing decompositions, and heuristics for detecting biases of vulgar reductionisms. This analysis of emergence is compatible with reduction. (shrink)

The text is the Russian translation of W. Whewell’s work “Novum Organon Renovatum” (Preface and Book I Aphorisms concerning ideas), which is the third edition of the second volume of his major work “The philosophy of the Inductive Sciences founded upon their History”. In the text, W. Whewell proposes his theory of scientific method and classification of the necessary scientific ideas as a basis, from where every particular scientific discipline derives. By adopting the structure of the notorious Francis Bacon’s “Novum (...) Organon”, Whewell reverses the order of scientific genesis, opposing himself to inductivism – the most influential philosophical theory of his time. (shrink)

This chapter explains that most of the standard objections to substance dualism (SD) count as effectively against property dualism (PD), and that PD is hardly more plausible, or less implausible, than SD. Dualism competes, not with neuroscience (a science), but with materialism, an opposing philosophical theory. The chapter shows that although Cartesian dualism faces some serious objections, that does not distinguish it from other philosophical theories, and the objections are not an order of magnitude worse than those confronting materialism in (...) particular. There remain the implausibilities required by the Cartesian view; but bare claim of implausibility is not argument. The dialectical upshot is that, on points, and going just by actual arguments as opposed to appeals to decency and what good guys believe, materialism is not significantly better supported than dualism. (shrink)

This book presents and survey of the foundations of mathematics. The emphasis is on a mathematical comparison of systems rather than on any exhaustive development of analysis within a single system. Nevertheless, for most systems considered, enough details are given for the development of arithmetic, and the method of constructing the other notions of analysis is indicated. The elements of the general theory of cardinal and ordinal numbers are also furnished in the course of this work.

Silent thinking is often accompanied by subvocal sayings to ourselves, imagery, emotional feelings, and non-sensory experiences such as familiarity, rightness, and confidence that we can go on in certain ways. Phenomenological materials of these kinds, along with our dispositions to give explanations or draw inferences, provide resources that are sufficient to account for our knowledge of what we think, desire, and so on. We do not need to suppose that there is a distinctive, non-imagistic 'what it is like' to think (...) that p, and a different non-imagistic 'what it is like' to think that q. Nor need we suppose that there is a proprietary 'what it is like' to have one propositional attitude type rather than another. (shrink)

The sentiment of rationality.--The dilemma of determinism.--The moral philosopher and the moral life.--The will to believe.--Conclusions on varieties of religious experience.--What pragmatism means.--Pragmatism's conception of truth.

This essay re-examines Meinong's "Über Gegenstandstheorie" and undertakes a clarification and revision of it that is faithful to Meinong, overcomes the various objections to his theory, and is capable of offering solutions to various problems in philosophy of mind and philosophy of language. I then turn to a discussion of a historically and technically interesting Russell-style paradox (now known as "Clark's Paradox") that arises in the modified theory. I also examine the alternative Meinong-inspired theories of Hector-Neri Castañeda and Terence Parsons.

This study is an unusual contribution to the philosophy of mind in that it argues for the sometimes unfashionable view of dualism: that mind and matter are distinct and separate entities as Descartes believed. The author takes as his point of departure the imaginative hypothesis of disembodiment, which establishes the possibility of the mind's being a quite non-material thing. There are clear casual correlations between what is physical and what is mental, and the most serious issue confronting dualism since Descartes (...) has been how such an interaction is possible. Dr Hart sets out to answer this question by showing that the issue is as much about the nature of causation as it is about the natures of mind and matter. (shrink)

Contemporaries often reject epiphenomenalism out of hand, while Russellian Monism is regarded as worthy of further development. It is argued here that this difference of attitudes is indefensible, because the easy rejection of EPI is due to its violating a certain Causal Intuition, and RM implicitly violates that same intuition. An enriched version of RM mitigates the violation, but the same mitigation results if we make a parallel enrichment of EPI. If RM and EPI are approached on a level playing (...) field, it is not obvious which will prove to be the better view. (shrink)

Combining engaging discussions and stimulating new case studies, BUSINESS ETHICS: A TEXTBOOK WITH CASES gives students a comprehensive survey of business ethics that will guide them toward becoming ethical professionals, even if they have never studied philosophy before. Rich with real-world examples, BUSINESS ETHICS: A TEXTBOOK WITH CASES invites students to critically analyze and apply a broad range of philosophical concepts and principles to today's most important issues in business and beyond. BUSINESS ETHICS: A TEXTBOOK WITH CASES is a concise (...) (without readings) and updated version of the eleventh edition of MORAL ISSUES IN BUSINESS. BUSINESS ETHICS: A TEXTBOOK WITH CASES is also available in an eBook format. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

Evidentialists say that a necessary condition of sound epistemic reasoning is that our beliefs reflect only our evidence. This thesis arguably conflicts with standard Bayesianism, due to the importance of prior probabilities in the latter. Some evidentialists have responded by modelling belief-states using imprecise probabilities (Joyce 2005). However, Roger White (2010) and Aron Vallinder (2018) argue that this Imprecise Bayesianism is incompatible with evidentialism due to “inertia”, where Imprecise Bayesian agents become stuck in a state of ambivalence towards hypotheses. Additionally, (...) escapes from inertia apparently only create further conflicts with evidentialism. This dilemma gives a reason for evidentialist imprecise probabilists to look for alternatives without inertia. I shall argue that Henry E. Kyburg’s approach offers an evidentialist-friendly imprecise probability theory without inertia, and that its relevant anti-inertia features are independently justified. I also connect the traditional epistemological debates concerning the “ethics of belief” more systematically with formal epistemology than has been hitherto done. (shrink)

Horton and Gerrig outlined a memory-based processing model of conversational common ground that provided a description of how speakers could both strategically and automatically gain access to information about others through domain-general memory processes acting over ordinary memory traces. In this article, we revisit this account, reviewing empirical findings that address aspects of this memory-based model. In doing so, we also take the opportunity to clarify what we believe this approach implies about the cognitive psychology of common ground, and just (...) as important, what it does not imply. We also highlight related areas of research demonstrating how general cognitive processes can constrain access to relevant knowledge in ways that shape both language production and comprehension. (shrink)

This article defends epiphenomenalism against criticisms raised in Dwayne Moore’s “On Robinson’s Response to the Self-Stultifying Objection”.

This is a very important book. It has already become required reading for researchers on the relation between the exact sciences and Kant’s philosophy. The main theme is that Kant’s continuing program to find a metaphysics that could provide a foundation for the science of his day is of crucial importance to understanding the development of his philosophical thought from its earliest precritical beginnings in the thesis of 1747, right through the highwater years of the critical philosophy, to his last (...) unpublished writings in the Opus postumum. In the course of articulating this theme, Friedman has made extensive use of detailed historical information about their scientific and mathematical background to illuminate Kant’s texts. Over and over again, such information is used to suggest interesting and quite subtle interpretations for texts that may have seemed puzzling or just wrong-headed. (shrink)

Studie over het werk van de Britse wijsgeer Gilbert Ryle (1900-1976).

This paper concerns the rational reconstruction of physical theories initially advanced by F. P. Ramsey and later elaborated by Rudolf Carnap. The Carnap–Ramsey reconstruction of theoretical knowledge is a natural development of classical empiricist ideas, one that is informed by Russell's philosophical logic and his theories of propositional understanding and knowledge of matter ; as such, it is not merely a schematic representation of the notion of an empirical theory, but the backbone of a general account of our knowledge of (...) the physical world. Carnap–Ramsey is an illuminating approach to epistemological problems that remain with us, one whose difficulties are shared by accounts that have sought to replace it. 1 Introduction 2 Russell's theory of propositional understanding 3 Ramsey's primary and secondary systems 4 Carnap's reconstruction of the language of science and an observation of Newman 5 Extension of the foregoing to constructive empiricism 6 Putnam's model-theoretic argument and the semantic view of theories 7 The problem clarified and resolved. (shrink)

Interdisciplinary research has been a popular idea with many people in the last 20 years. Academic administrators have admonished their faculty to become more interdisciplinary. Students often request the chance to pursue an interdisciplinary degree. While the issue of managing interdisciplinary projects has received a fair amount of attention by those interested in science management, interdisciplinary research has received little attention from historians, philosophers or sociologists of science or from scientists themselves. Yet, there l;lre a number of cases within the (...) life sciences where researchers have been actively engaged in endeavors that take them across disciplinary boundaries. These are ripe for investigation by those interested in the process of science. To provide an in-depth study of some historical or contemporary cases of cross disciplinary research activity in the life sciences, a conference was held at Georgia State University in May, 1984. This conference was supported by the National Endowment for the Humanities (U. S. A. ) through their research conference program. Over a three-day period historians, philosophers, and researchers who were actively engaged in various of the life sciences discussed specific examples of interdisciplinary research and tried to analyze what was needed for successful crossing of disciplinary boundaries. After the conference, each of the participants revised their original presentations, partly in light of the discussion at the conference. The papers in this volume are the fruits of that endeavor. (shrink)

Eating is a fundamental behavior in which all organisms must engage in order to procure the material and energy from their environment that they need to maintain themselves. Since controlling eating requires procuring, processing, and assessing information, it constitutes a cognitive activity that provides a productive domain for pursuing cognitive biology as proposed by Ladislav Kováč. In agreement with Kováč, we argue that cognition is fundamentally grounded in chemical signaling and processing. To support this thesis, we adopt Cisek’s strategy of (...) phylogenetic refinement, focusing on two animal phyla, Porifera and Placozoa, organisms that do not have neurons, muscles, or an alimentary canal, but nonetheless need to coordinate the activity of cells of multiple types in order to eat. We review what research has revealed so far about how these animals gather and process information to control their eating behavior. (shrink)

In a careful exposition of French Marxism, William Lewis places Althusser and his thought alongside the pre- and post-war French communist intellectual climate: the result is an excellent and unique work. Part theoretical treatise on some of Althusser's more complicated and less explored ideas, part intellectual history, Louis Althusser and the Traditions of French Marxism is, in total, an important text for philosophy, French and francophone studies, political thought, cultural studies, marxist thought, and several other disciplines interested in the intellectual (...) life and times of the twientieth century. (shrink)

We investigated the properties of the sustained attention to response task . In the SART, participants respond to frequent neutral signals and are required to withhold response to rare critical signals. We examined whether SART performance shows characteristics of speed–accuracy tradeoffs and in addition, we examined whether SART performance is influenced by prior exposure to emotional picture stimuli. Thirty-six participants in this study performed SARTs after being exposed to neutral and negative picture stimuli. Performance in the SART changed rapidly over (...) time and there was a high correlation between participants errors of commission rate and their reaction time to the neutral targets . Regardless of exposure self-reported thoughts significantly correlated with both errors of commission and reaction times. Overall, the results support the view that the SART is a better measure of impulsive responding than sustained attention. (shrink)

According to epiphenomenalism, our behavior is caused by events in our brains that also cause our mentality. This resulting mentality reflects our brains¿ organization, but does not in turn cause anything. This book defends an epiphenomenalist account of philosophy of mind. It builds on the author¿s previous work by moving beyond a discussion of sensations to apply an epiphenomenalist outlook to other aspects of mental causation such as beliefs, desires, pleasure, and displeasure. The first four chapters of the book argue (...) for a dualistic theory of sensations and develop an epiphenomenalist version of dualism. The remaining chapters discuss propositional attitudes and valence. The author also responds to potential objections to epiphenomenalism by considering how sensations, intelligence, or understanding might be built into a robot. This book will be of interest to scholars and students in philosophy of mind who are interested in consciousness, mental causation, and how our mentality is situated in the world. (shrink)

Beliefs are freely attributed to God nowadays in Anglo–American philosophical theology. This practice undoubtedly reflects the twentieth–century popularity of the view that knowledge consists of true justified belief . The connection is frequently made explicit. If knowledge is true justified belief then whatever God knows He believes. It would seem that much recent talk of divine beliefs stems from Nelson Pike's widely discussed article, ‘Divine Omniscience and Voluntary Action’. In this essay Pike develops a version of the classic argument for (...) the incompatibility of divine foreknowledge and free will in terms of divine forebelief. He introduces this shift by premising that ‘ A knows X ’ entails ‘A believes X ’. As a result of all this, philosophers have increasingly been using the concept of belief in defining ‘omniscience’. (shrink)

This paper begins with a summary of an argument for epiphenomenalism and a review of the author's previous work on the self-stultification objection to that view. The heart of the paper considers an objection to this previous work and provides a new response to it. Questions for this new response are considered and a view is developed in which knowledge of our own mentality is seen to differ from our knowledge of external things.

The development and consultation experience of an ethics committee in an urban community hospital has been presented, and various approaches to case consultation have been considered. Our committee has concentrated on the clinical evaluation model. As expected, most consultations have centered on issues of withdrawing or limiting medical care. Most patients evaluated have been unable to clearly express their wishes concerning further treatments, highlighting the need for promoting advance directives. When resorting to substituted judgment, our committee has supported continued care (...) in a majority of cases. Limitation of the consultation process to the attending physician has, in our experience, actually served to increase the credibility of the committee and has promoted acceptance of its recommendations. The committee's most useful function seems to be in assisting physicians and their patients in defining realistic goals and limitations of treatment. Within this context, the coming decade may find ethics committees concerned less with promoting the autonomous wishes of individual patients than with defining the limits of that autonomy against the competing demands of the larger society. Such a shift be approached with caution. (shrink)